The biggest game in America, NFL combines galaxy-brain strategy with extreme skill, elite athleticism and bone-crunching tackles. You can bet on American football and the NFL here at William Hill, with our amazing range of NFL betting markets on everything from the Super Bowl winner and MVP to point spreads and handicaps on each game from around the league.

Every year in the NFL, 32 teams take to the field across America in the regular season with a view to booking their spot in the post-season playoffs – and ultimately, lifting the Vince Lombardi trophy at the end of it all.

Once the season gets underway, you'll be able to bet on every game around the NFL – whether that's a straight win (money line markets) bet or a handicap.

You can bet on the point spreads on individual NFL games throughout the season, also known as NFL handicap betting or betting lines. Handicap betting  is a popular way to bet on American football, particularly when there is a strong favourite against an underdog.

Unlike money line bets where you back a winner of a specific game, NFL handicap betting is when you pick which side of a given points margin a game will end on. It means you can win your bet even if a team loses, as long as they do so by a lower margin than the handicap given for that game.

For each NFL game you'll find a point-spread market based on who is the favourite: for example, the Kansas City Chiefs may be listed as three-and-a-half point favourites for their next game against the Buffalo Bills. The handicap for this game would be shown as Chiefs -3.5, Bills +3.5.

- The Chiefs are favourites as they are the minus handicap (-3.5)

- If you think the Chiefs will win by more than 3.5 points over the Bills, you would bet on the Chiefs -3.5

- If you want to go the other way, you will be betting on the Bills to win the game outright, or, at the very least, lose by less than 3.5 points

In this example, let's say the Chiefs beat the Bills 30-28.

- If you bet on the Chiefs -3.5, then you deduct 3.5 points from their final score. In this case that would leave an adjusted score of Chiefs 26.5, Bills 28. Even though the Chiefs won the game, they won by less than the -3.5 margin of the handicap, so this would be a losing bet.

- If you bet on the Bills +3.5, then you add 3.5 points to their final score. That would leave an adjusted score of Chiefs 30, Bills 31.5. Even though the Bills lost the game, they did so by less than the +3.5 margin of the handicap, so this would be a winning bet. This is also known as “covering the spread” or simply “covering”.

The next Super Bowl is the 60th in history, officially known as Super Bowl LX. It will take place at Levi’s Stadium in Santa Clara, California, on Sunday, 8th February 2026. Here at William Hill, you'll find an incredible range of betting markets on the Super Bowl, where you can pick everything from the outright winner to the MVP, the winning margin, the first touchdown scorer and lots, lots more.

Every year, the Super Bowl is contested by the top teams from the NFC and AFC, with the winners of each conference's championship game progressing through to the biggest stage in NFL.

You can bet on a wide variety of markets on the next Super Bowl, including player-specific odds such as:

- Touchdown scorers

- Rushing, passing and receiving yards

- Player match-ups: will one player outdo the other in a direct comparison?

And keep your eyes peeled for our novelty Super Bowl betting markets, which feature even more inventive markets for the biggest game in American football.

The NFL's 32 teams are divided into two conferences – the American Football Conference (AFC) and National Football Conference (NFC). Each conference contains 16 teams, split into four divisions of four teams each – the North, South, East and West.

Every season, teams play the other three teams in their division twice, home and away, with the rest of the 17-game schedule made up of other teams from around the NFL. The prize for winning a division is a guaranteed spot in the post-season playoffs, with wildcard spots available to other teams who finish with the best records.

At William Hill, you can bet on the winners of each of the NFL's divisions, and there's always plenty of surprises throughout the season as some teams rise and others fade away unexpectedly.

You can also bet on the winners of each conference, the AFC and NFC. This is determined through the playoffs, where teams face off in single-game elimination until two teams are left in each conference. Those teams play in the AFC and NFC Championship games, with the winner of each heading to the Super Bowl for the ultimate prize in the sport.

Every year the NFL crowns its MVP: the Most Valuable Player as voted for by his peers. You can bet on the recipient of this prestigious award every season, along with other player awards such as the Rookies of the Year and the Defensive and Offensive Players of the Year.

The superstars of the future are chosen every year in the NFL draft, as a whole new crop of young players are selected out of college football in a seven-round draft by all 32 teams. Typically, the team with the worst record from the previous season will make the first pick in the draft, giving struggling teams a chance to make a swift turnaround if they can unearth a generational talent.

There's more to American Football than just the NFL, with College Football played throughout the autumn and pulling in huge crowds. You can bet on all the action from the National Collegiate Athletic Association (NCAA) here at William Hill, with a huge variety of markets during the season including the winner of the Heisman Trophy for MVP.

The NFL can be an unpredictable league, particularly before a ball has been kicked off or a pass thrown. Here's some quick tips to hopefully give you an edge when it comes to betting on NFL.

- Check the form: how are a team playing? Are they on an unbeaten run, or have they been on a losing streak? Is their home stadium a fortress where they're a match for any opponent, or have they been pushovers in front of their own fans?

- Injuries: is the star quarterback injured? Is this the week the leading wide receiver returns to the line-up? Teams are required to disclose injury statuses of players every week, so keep a close eye on the injury report before picking your bets.

- Playing conditions: NFL is an outdoor sport, although some teams play in domes. For those without a roof, however, the weather can be a huge factor. Check the playing conditions before you bet: a downpour of rain could be a leveller between two otherwise-mismatched teams, while others might buckle if not used to the scorching heat of Miami or the high altitude of Denver's Mile High Stadium.

- Check the stats: whether you want to know how an individual player has been performing, such as how many touchdowns they have or how many yards they've gained, there are plenty of stats out there to help. You can also check our American football and NFL tips  in our news site.

There are always great offers and promotions to take advantage of when betting on NFL online with William Hill:

- Top Price Guarantee – unbeatable prices on selected Enhance Odds

- Price boost – boosted prices on certain NFL markets every week

- #YourOdds – can't find the NFL betting market you want? Just tweet us with #YourOdds and we'll price up your bet.

Looking for boosted prices on American Football and other sports? Check out our latest betting promotions.